MTHFR activates 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate (5-MTHF). While MTHFR is a key enzyme involved in serotonin, dopamine, and catecholamine production, catechol-O-methyltransferase (COMT) is the enzyme responsible for degradation of catecholamines. Knowing if you have a mutation in either of these can provide valuable insight into your health and well-being.
MTHFR & COMT
This test is an at-home mouth swab lab.
Do you suffer from:
ADD (attention deficit disorder)
Addictive behavior
ADHD (Attention deficit hyperactivity disorder)
Allergies
Anxiety
Autism
Bipolar disorder
Cancer
Cardiovascular disease: thromboembolism, atherosclerosis and myocardial infarction
Chemical sensitivity
Chronic fatigue syndrome
Chronic viral infectionCleft palate
Dementia and memory loss
Depression
Down’s syndrome
Electromagnetic hypersensitivity
Elevated homocysteine
Fibromyalgia
Homocysteine imbalance
HPV (Human papillomavirus)
Immune deficiency
Insomnia
Migraine
MS (Multiple Sclerosis)
Neural tube and other birth defects
Parkinsons disease
PCOS (Polycystic Ovarian Syndrome)
Pulmonary Embolism
Recurrent Miscarriage
Reduced lean body mass and increased body fat
Schizophrenia
Spina bifida
Stroke
Thyroid Dysfunction
If you said yes to more than 1 of the above, this test may be a great option for you!
COMT has also been demonstrated to play a role in estrogen metabolism through inactivation of the catecholestrogens. Catecholestrogens are formed during the metabolism of estrogens such as estradiol. Catecholestrogen inactivation decreases the cancer-causing potential of these metabolites, while simultaneously increasing the amount of 2-methoxyestradiol, a metabolite that has been shown to inhibit the growth of breast cancer cells.
Identifying both MTHFR and COMT status is often helpful. People with reduced COMT activity may be more sensitive to folate supplements, as folate can increase neurotransmitter levels. If both MTHFR and COMT are slow, it’s usually best to address COMT first.
*Labs Expire 6 months after purchase.
*This is for the MTHFR & COMT lab ONLY! A consultation is an additional add-on service.